2,4'-dihydroxyacetophenone dioxygenase

In enzymology, a 2,4'-dihydroxyacetophenone dioxygenase (EC 1.13.11.41) is an enzyme that catalyzes the chemical reaction

2,4'-dihydroxyacetophenone + O2 4-hydroxybenzoate + formate
2,4'-dihydroxyacetophenone dioxygenase
Identifiers
EC number1.13.11.41
CAS number105503-64-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 2,4'-dihydroxyacetophenone and O2, whereas its two products are 4-hydroxybenzoate and formate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving). This enzyme is also called (4-hydroxybenzoyl)methanol oxygenase. This enzyme participates in bisphenol a degradation.[1]

References

  1. Enya M, Aoyagi K, Hishikawa Y, Yoshimura A, Mitsukura K, Maruyama K (2012). "Molecular and catalytic properties of 2,4'-dihydroxyacetophenone dioxygenase from Burkholderia sp. AZ11". Bioscience, Biotechnology, and Biochemistry. 76 (3): 567–74. doi:10.1271/bbb.110867. PMID 22451401.
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