19,20-Dihydroervahanine A
19,20-Dihydroervahanine A is an alkaloid, a natural product which is found in the root of the South-East Asian plant Tabernaemontana divaricata.[1]
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Formula | C42H52N4O4 |
Molar mass | 676.902 g·mol−1 |
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It acts as a potent acetylcholinesterase inhibitor, thus could be beneficial for dementia and Alzheimer's disease. It is a reversible inhibitor with more inhibitory activity than a well known drug galantamine.[2]
References
- Ingkaninan K, Changwijit K, Suwanborirux K (June 2006). "Vobasinyl-iboga bisindole alkaloids, potent acetylcholinesterase inhibitors from Tabernaemontana divaricata root". The Journal of Pharmacy and Pharmacology. 58 (6): 847–52. doi:10.1211/jpp.58.6.0015. PMID 16734986.
- Pratchayasakul W, Pongchaidecha A, Chattipakorn N, Chattipakorn S (April 2008). "Ethnobotany & ethnopharmacology of Tabernaemontana divaricata" (PDF). The Indian Journal of Medical Research. 127 (4): 317–35. PMID 18577786.
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