1-hydroxy-2-naphthoate hydroxylase

1-hydroxy-2-naphthoate hydroxylase (EC 1.14.13.135, 1-hydroxy-2-naphthoic acid hydroxylase) is an enzyme with systematic name 1-hydroxy-2-naphthoate,NAD(P)H:oxygen oxidoreductase (2-hydroxylating, decarboxylating).[1][2] This enzyme catalyses the following chemical reaction

1-hydroxy-2-naphthoate + NAD(P)H + H+ + O2 1,2-dihydroxynaphthalene + NAD(P)+ + H2O + CO2
1-hydroxy-2-naphthoate hydroxylase
Identifiers
EC number1.14.13.135
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

1-hydroxy-2-naphthoate hydroxylase is involved in chrysene degradation in some bacteria.

References

  1. Deveryshetty J, Phale PS (October 2010). "Biodegradation of phenanthrene by Alcaligenes sp. strain PPH: partial purification and characterization of 1-hydroxy-2-naphthoic acid hydroxylase". FEMS Microbiology Letters. 311 (1): 93–101. doi:10.1111/j.1574-6968.2010.02079.x. PMID 20727010.
  2. Nayak AS, Sanjeev Kumar S, Santosh Kumar M, Anjaneya O, Karegoudar TB (July 2011). "A catabolic pathway for the degradation of chrysene by Pseudoxanthomonas sp. PNK-04". FEMS Microbiology Letters. 320 (2): 128–34. doi:10.1111/j.1574-6968.2011.02301.x. PMID 21545490.
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