1-alkylglycerophosphocholine O-acyltransferase
In enzymology, a 1-alkylglycerophosphocholine O-acyltransferase (EC 2.3.1.63) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine CoA + 2-acyl-1-alkyl-sn-glycero-3-phosphocholine
| 1-alkylglycerophosphocholine O-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.63 | ||||||||
| CAS number | 58693-63-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acyl-CoA and 1-alkyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 2-acyl-1-alkyl-sn-glycero-3-phosphocholine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase. This enzyme participates in ether lipid metabolism.
References
- Waku K, Nakazawa Y (October 1970). "Acyltransferase activity to 1-O-alkyl-glycero-3-phosphorylcholine in sarcoplasmic reticulum". J. Biochem. Tokyo. 68 (4): 459–66. PMID 5488773.
- Waku K, Nakazawa Y (August 1972). "Acyltransferae activity to 1-acyl-, 1-O-alkenyl-, and 1-O-alkyl-glycero-3-phosphorylcholine in Ehrlich ascites tumor cells". J. Biochem. Tokyo. 72 (2): 495–7. PMID 4644313.
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