(heparan sulfate)-glucosamine N-sulfotransferase
In enzymology, a [heparan sulfate]-glucosamine N-sulfotransferase (EC 2.8.2.8) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
| [heparan sulfate]-glucosamine N-sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.8 | ||||||||
| CAS number | 9026-75-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and heparan sulfate-glucosamine, whereas its two products are adenosine 3',5'-bisphosphate and heparan sulfate-N-sulfoglucosamine.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase. Other names in common use include heparin N-sulfotransferase, 3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase, PAPS:N-desulfoheparin sulfotransferase, PAPS:DSH sulfotransferase, N-HSST, N-heparan sulfate sulfotransferase, heparan sulfate N-deacetylase/N-sulfotransferase, heparan sulfate 2-N-sulfotransferase, heparan sulfate N-sulfotransferase, heparan sulfate sulfotransferase, N-desulfoheparin sulfotransferase, desulfoheparin sulfotransferase, 3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase, heparitin sulfotransferase, and 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase.
References
- Suzuki S, Trenn RH, Strominger JL (1961). "Separation of specific mucopolysaccharide sulfotransferases". Biochim. Biophys. Acta. 50: 169–174. doi:10.1016/0006-3002(61)91075-7.
- Eisenman RA, Balasubramanian AS, Marx W (1967). "3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction". Arch. Biochem. Biophys. 119 (1): 387–97. doi:10.1016/0003-9861(67)90470-5. PMID 4964017.
- Johnson AH, Baker JR (1973). "The enzymatic sulphation of heparan sulphate by hen's uterus". Biochim. Biophys. Acta. 320 (2): 341–51. doi:10.1016/0304-4165(73)90314-0. PMID 4270798.