(cytochrome c)-lysine N-methyltransferase

In enzymology, a [cytochrome c]-lysine N-methyltransferase (EC 2.1.1.59) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + [cytochrome c]-L-lysine S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine
[cytochrome c]-lysine N-methyltransferase
Identifiers
EC number2.1.1.59
CAS number82047-78-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and cytochrome c-L-lysine, whereas its two products are S-adenosylhomocysteine and cytochrome c-N6-methyl-L-lysine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase. Other names in common use include cytochrome c (lysine) methyltransferase, cytochrome c methyltransferase, cytochrome c-specific protein methylase III, cytochrome c-specific protein-lysine methyltransferase, S-adenosyl-L-methionine:[cytochrome c]-L-lysine, and 6-N-methyltransferase. This enzyme participates in lysine degradation.

References

    • Durban E, Nochumson S, Kim S, Paik WK, Chan SK (1978). "Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements". J. Biol. Chem. 253 (5): 1427–35. PMID 203592.
    • Nochumson S, Durban E, Kim S, Paik WK (1977). "Cytochrome c-specific protein methylase III from Neurospora crassa". Biochem. J. 165 (1): 11–8. PMC 1164862. PMID 196592.
    • Valentine J, Pettigrew GW (1982). "A cytochrome c methyltransferase from Crithidia oncopelti". Biochem. J. 201 (2): 329–38. PMC 1163647. PMID 6282265.


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