(RS)-norcoclaurine 6-O-methyltransferase
In enzymology, a (RS)-norcoclaurine 6-O-methyltransferase (EC 2.1.1.128) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + (RS)-norcoclaurine S-adenosyl-L-homocysteine + (RS)-coclaurine
| (RS)-norcoclaurine 6-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.128 | ||||||||
| CAS number | 167398-06-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and (R,S)-norcoclaurine, whereas its two products are S-adenosylhomocysteine and (R,S)-coclaurine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.
References
- Rueffer M, Nagakura N, Zenk MH (1983). "Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures". Planta Med. 49 (11): 131–137. doi:10.1055/s-2007-969833. PMID 17405035.
- Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y (1994). "Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells". Eur. J. Biochem. 225 (1): 125–31. doi:10.1111/j.1432-1033.1994.00125.x. PMID 7925429.
- Stadler R, Zenk MH (1990). "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline". Liebigs Ann. Chem.: 555–562.
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