(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase (EC 1.13.11.80, DpgC) is an enzyme[1] catalyses the following chemical reaction

(3,5-dihydroxyphenyl)acetyl-CoA + O2 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA.
(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase hexamer, Streptomyces toyocaensis
Identifiers
EC number1.13.11.80
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is involved in the biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. It catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate.

References

  1. Fielding EN, Widboom PF, Bruner SD (December 2007). "Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC". Biochemistry. 46 (49): 13994–4000. doi:10.1021/bi701148b. PMID 18004875.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.