(2Z,6Z)-farnesyl diphosphate synthase

(2Z,6Z)-farnesyl diphosphate synthase (EC 2.5.1.92, cis,cis-farnesyl diphosphate synthase, Z,Z-FPP synthase, zFPS, Z,Z-farnesyl pyrophosphate synthase) is an enzyme with systematic name dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units).[1] This enzyme catalyses the following chemical reaction

dimethylallyl diphosphate + 2 isopentenyl diphosphate 2 diphosphate + (2Z,6Z)-farnesyl diphosphate
(2Z,6Z)-farnesyl diphosphate synthase
Identifiers
EC number2.5.1.92
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme was originally characterized from wild tomato.

References

  1. Sallaud C, Rontein D, Onillon S, Jabès F, Duffé P, Giacalone C, Thoraval S, Escoffier C, Herbette G, Leonhardt N, Causse M, Tissier A (January 2009). "A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites". The Plant Cell. 21 (1): 301–17. doi:10.1105/tpc.107.057885. PMC 2648096. PMID 19155349.
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