ZRF1

DNAJC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M2E
Identifiers
Aliases	DNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1, DnaJ heat shock protein family (Hsp40) member C2
External IDs	MGI: 99470 HomoloGene: 31656 GeneCards: DNAJC2
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	103,344,873 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	21,785,251 bp[2]
Gene ontology
Molecular function	• DNA binding; • Hsp70 protein binding; • histone binding; • chromatin binding; • ATPase activator activity; • RNA binding; • ubiquitin modification-dependent histone binding; • protein binding;
Cellular component	• cytoplasm; • cytosol; • nuclear membrane; • cell nucleus; • nucleoplasm;
Biological process	• positive regulation of transcription, DNA-templated; • regulation of cellular response to heat; • DNA replication; • 'de novo' cotranslational protein folding; • regulation of transcription, DNA-templated; • negative regulation of DNA biosynthetic process; • transcription, DNA-templated; • positive regulation of ATPase activity; • covalent chromatin modification;
	Sources:Amigo / QuickGO
Orthologs
	27000
	22791
	ENSG00000105821
	ENSMUSG00000029014
	Q99543
	P54103
	NM_001129887; NM_014377; NM_001362667; NM_001362668
	NM_009584
	NP_001123359; NP_055192; NP_001349596; NP_001349597
	NP_033610
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2 gene.^[5]^[6]

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105821 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029014 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
1 2 "Entrez Gene: ZRF1 zuotin related factor 1".

Resto VA, Caballero OL, Buta MR, et al. (2000). "A putative oncogenic role for MPP11 in head and neck squamous cell cancer". Cancer Res. 60 (19): 5529–35. PMID 11034098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Greiner J, Ringhoffer M, Taniguchi M, et al. (2003). "Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia". Int. J. Cancer. 106 (2): 224–31. doi:10.1002/ijc.11200. PMID 12800198.
Greiner J, Ringhoffer M, Taniguchi M, et al. (2004). "mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies". Int. J. Cancer. 108 (5): 704–11. doi:10.1002/ijc.11623. PMID 14696097.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hundley HA, Walter W, Bairstow S, Craig EA (2005). "Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous". Science. 308 (5724): 1032–4. doi:10.1126/science.1109247. PMID 15802566.
Otto H, Conz C, Maier P, et al. (2005). "The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10064–9. doi:10.1073/pnas.0504400102. PMC 1177401. PMID 16002468.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105821 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029014 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8885239-5] Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.

[entrez-6] 1 2 "Entrez Gene: ZRF1 zuotin related factor 1".

ZRF1

References

Further reading