ZBTB1

ZBTB1
Identifiers
Aliases	ZBTB1, ZNF909, zinc finger and BTB domain containing 1
External IDs	MGI: 2442326 HomoloGene: 8974 GeneCards: ZBTB1
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	64,533,690 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	76,396,950 bp[2]
Gene ontology
Molecular function	• DNA binding; • protein homodimerization activity; • metal ion binding; • K63-linked polyubiquitin modification-dependent protein binding; • protein binding; • protein heterodimerization activity; • nucleic acid binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding;
Cellular component	• nuclear body; • nucleoplasm; • cell nucleus; • nuclear membrane;
Biological process	• positive regulation of T cell differentiation; • chromatin remodeling; • cell differentiation; • positive regulation of pro-T cell differentiation; • regulation of transcription, DNA-templated; • positive regulation of natural killer cell differentiation; • T cell differentiation in thymus; • thymus development; • immune system process; • cellular response to UV; • mRNA transcription from RNA polymerase II promoter; • negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • positive regulation of T cell mediated immunity; • translesion synthesis; • B cell differentiation; • innate immune response; • protein homooligomerization; • DNA repair; • cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	22890
	268564
	ENSG00000126804
	ENSMUSG00000033454
	Q9Y2K1
	Q91VL9
	NM_001123329; NM_014950
	NM_178744; NM_001364323
	NP_001116801; NP_055765
	NP_848859; NP_001351252
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.^[5]

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000126804 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033454 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Zinc finger and BTB domain containing 1".
↑ Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.
↑ Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000126804 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033454 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Zinc finger and BTB domain containing 1".

[pmid22201126-6] Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.

[pmid22753936-7] Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.