ZBED6

ZBED6
Identifiers
Aliases	ZBED6, MGR, zinc finger BED-type containing 6
External IDs	MGI: 3828086 HomoloGene: 130066 GeneCards: ZBED6
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	203,854,999 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	133,660,885 bp[2]
Gene ontology
Molecular function	• DNA binding; • protein dimerization activity; • metal ion binding; • transcription factor activity, sequence-specific DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding;
Cellular component	• nucleolus; • cell nucleus;
Biological process	• negative regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	100381270
	667118
	ENSG00000257315
	ENSMUSG00000102049
	P86452
	D2EAC2
	NM_001174108
	NM_001166552
	NP_001167579
	NP_001160024
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger, BED-type containing 6 is a protein that in humans is encoded by the ZBED6 gene.^[5]

References

Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barrés R, Yan J, Strömberg S, De S, Pontén F, Lander ES, Carr SA, Zierath JR, Kullander K, Wadelius C, Lindblad-Toh K, Andersson G, Hjälm G, Andersson L (Dec 2009). O'Rahilly S, ed. "ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth". PLoS Biology. 7 (12): e1000256. doi:10.1371/journal.pbio.1000256. PMC 2780926. PMID 20016685.
Butter F, Kappei D, Buchholz F, Vermeulen M, Mann M (Apr 2010). "A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth". EMBO Reports. 11 (4): 305–11. doi:10.1038/embor.2010.6. PMC 2854606. PMID 20134481.
Andersson L (2010). "Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin". Cold Spring Harbor Symposia on Quantitative Biology. 74: 319–25. doi:10.1101/sqb.2009.74.039. PMID 20375320.

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