Young's syndrome

Young's syndrome
Young's syndrome is inherited in an autosomal recessive manner

Young's syndrome, also known as azoospermia sinopulmonary infections, sinusitis-infertility syndrome and Barry-Perkins-Young syndrome, is a rare condition that encompasses a combination of syndromes such as bronchiectasis, rhinosinusitis and reduced fertility.[1][2][3] In individuals with this syndrome, the functioning of the lungs is usually normal but the mucus is abnormally viscous. The reduced fertility (azoospermia) is due to functional obstruction of sperm transport down the genital tract at the epididymis where the sperms are found in viscous, lipid-rich fluid.[3][4] The syndrome was named after Donald Young,[5] the urologist who first made observations of the clinical signs of the syndrome in 1972.[6] There have been several studies undertaken suggesting that contact with mercury might cause the syndrome.[7] A variant of Young's syndrome has been observed in an individual, showing slightly different signs and symptoms.[8]

See also

References

  1. ↑ Handelsman DJ, Conway AJ, Boylan LM, Turtle JR (January 1984). "Young's syndrome. Obstructive azoospermia and chronic sinopulmonary infections". N. Engl. J. Med. 310 (1): 3–9. doi:10.1056/NEJM198401053100102. PMID 6689737.
  2. ↑ Young syndrome at NIH's Office of Rare Diseases
  3. 1 2 Young's syndrome - General Practice Notebook
  4. ↑ Definition: Young syndrome from Online Medical Dictionary
  5. ↑ Young, M (January 2003). "Obituary of Donald Herron Young". BMJ. 326 (7382): 226. doi:10.1136/bmj.326.7382.226/g.
  6. ↑ Online Mendelian Inheritance in Man (OMIM) Young syndrome -279000
  7. ↑ Hendry WF, A'Hern RP, Cole PJ (1993). "Was Young's syndrome caused by exposure to mercury in childhood?". BMJ. 307 (6919): 1579–82. doi:10.1136/bmj.307.6919.1579. PMC 1697782. PMID 8292944.
  8. ↑ Shiraishi K, Ono N, Eguchi S, Mohri J, Kamiryo Y, Takihara H (2004). "Young's syndrome associated with situs inversus totalis". Arch. Androl. 50 (3): 169–72. doi:10.1080/01485010490425511. PMID 15204683.
  • Lau KY, Lieberman J (June 1986). "Young's syndrome. An association between male sterility and bronchiectasis". West. J. Med. 144 (6): 744–6. PMC 1306774. PMID 3727536.
Classification
External resources


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