YAF2

YAF2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesYAF2, YY1 associated factor 2
External IDsHomoloGene: 136401 GeneCards: YAF2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q12Start42,157,104 bp[1]
End42,238,349 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10138

n/a

Ensembl

ENSG00000015153

n/a

UniProt

Q8IY57

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001177906
NP_001177908
NP_001177909
NP_001307009
NP_005739

n/a

Location (UCSC)Chr 12: 42.16 – 42.24 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.[3][4]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000015153 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Mar 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
  4. 1 2 "Entrez Gene: YAF2 YY1 associated factor 2".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mädge B, Geisen C, Möröy T, Schwab M (2003). "Yaf2 inhibits Myc biological function". Cancer Lett. 193 (2): 171–6. doi:10.1016/S0304-3835(02)00696-1. PMID 12706874.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135.
  • Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
  • Bannasch D, Mädge B, Schwab M (2001). "Functional interaction of Yaf2 with the central region of MycN". Oncogene. 20 (41): 5913–9. doi:10.1038/sj.onc.1204747. PMID 11593398.


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