Xin Lu

Xin Lu
Alma mater
Works
  • ASPP proteins specifically stimulate the apoptotic function of p53
Awards
Website https://www.ndm.ox.ac.uk/principal-investigators/researcher/xin-lu
Scientific career
Institutions
Thesis A study of intermediate filament formation using retrovirus-mediated gene transfer
Doctoral advisor Ellen Birgit Lane

Xin Lu is a Professor of Cancer Biology and Director of the Ludwig Institute for Cancer Research at the University of Oxford.[1] She is known for her discovery of and research on the ASPP family of proteins.[2][3]

Education

Lu completed her undergraduate education in Biochemistry at Sichuan University in 1982 and her masters at Peking Union Medical College in 1985.[4] She moved to UCL [5] to complete her PhD studies supervised by Birgit Lane, and published her thesis A study of intermediate filament formation using retrovirus-mediated gene transfer in 1991.[6]

Research and career

In 1993, after a short postdoc with David Lane at Dundee University, Lu set up her own research group at the Ludwig Institute in London.[7][8] In 2004 Lu was appointed Director of the Ludwig Institute and in 2007 she moved the institute to Oxford.[9]

Honours and awards

Notable works

Lu, X. "Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?". Cell. 75 (4): 765–778. doi:10.1016/0092-8674(93)90496-d.

Hsieh, Jung-Kuang; Chan, Florence S.G; O’Connor, Daniel J; Mittnacht, Sibylle; Zhong, Shan; Lu, Xin. "RB Regulates the Stability and the Apoptotic Function of p53 via MDM2". Molecular Cell. 3 (2): 181–193. doi:10.1016/s1097-2765(00)80309-3.

Samuels-Lev, Yardena; O'Connor, Daniel J.; Bergamaschi, Daniele; Trigiante, Giuseppe; Hsieh, Jung-Kuang; Zhong, Shan; Campargue, Isabelle; Naumovski, Louie; Crook, Tim. "ASPP Proteins Specifically Stimulate the Apoptotic Function of p53". Molecular Cell. 8 (4): 781–794. doi:10.1016/s1097-2765(01)00367-7.

Lu, Min; Zak, Jaroslav; Chen, Shuo; Sanchez-Pulido, Luis; Severson, David T.; Endicott, Jane; Ponting, Chris P.; Schofield, Christopher J.; Lu, Xin. "A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway". Cell. 157 (5): 1130–1145. doi:10.1016/j.cell.2014.05.006.

Bergamaschi, Daniele; Samuels, Yardena; O'Neil, Nigel J.; Trigiante, Giuseppe; Crook, Tim; Hsieh, Jung-Kuang; O'Connor, Daniel J.; Zhong, Shan; Campargue, Isabelle (2003). "iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human". Nature Genetics. 33 (2): 162–167. doi:10.1038/ng1070. ISSN 1546-1718.

Notari, Mario; Hu, Ying; Sutendra, Gopinath; Dedeić, Zinaida; Lu, Min; Dupays, Laurent; Yavari, Arash; Carr, Carolyn A.; Zhong, Shan (2015-03-03). "iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death". Proceedings of the National Academy of Sciences. 112 (9): E973–E981. doi:10.1073/pnas.1408111112. PMC 4352828.

Wang, Yihua; Bu, Fangfang; Royer, Christophe; Serres, Sébastien; Larkin, James R.; Soto, Manuel Sarmiento; Sibson, Nicola R.; Salter, Victoria; Fritzsche, Florian (2014). "ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1". Nature Cell Biology. 16 (11): 1092–1104. doi:10.1038/ncb3050. ISSN 1476-4679.

Turnquist, Casmir; Wang, Yihua; Severson, David T.; Zhong, Shan; Sun, Bin; Ma, Jingyi; Constantinescu, Stefan N.; Ansorge, Olaf; Stolp, Helen B. (2014-07-08). "STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression". Proceedings of the National Academy of Sciences. 111 (27): 9834–9839. doi:10.1073/pnas.1407898111. PMC 4103354.

Lu, Min; Breyssens, Hilde; Salter, Victoria; Zhong, Shan; Hu, Ying; Baer, Caroline; Ratnayaka, Indrika; Sullivan, Alex; Brown, Nicholas R. "Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP". Cancer Cell. 23 (5): 618–633. doi:10.1016/j.ccr.2013.03.013.

Wang, Yihua; Wang, Xiao Dan; Lapi, Eleonora; Sullivan, Alexandra; Jia, Wei; He, You-Wen; Ratnayaka, Indrika; Zhong, Shan; Goldin, Robert D. (2012-08-14). "Autophagic activity dictates the cellular response to oncogenic RAS". Proceedings of the National Academy of Sciences. 109 (33): 13325–13330. doi:10.1073/pnas.1120193109.

Notari, Mario; Hu, Ying; Koch, Sofia; Lu, Min; Ratnayaka, Indrika; Zhong, Shan; Baer, Caroline; Pagotto, Anna; Goldin, Robert (2011-10-04). "Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification". Proceedings of the National Academy of Sciences. 108 (40): 16645–16650. doi:10.1073/pnas.1102292108.

Slee, Elizabeth A.; Benassi, Barbara; Goldin, Robert; Zhong, Shan; Ratnayaka, Indrika; Blandino, Giovanni; Lu, Xin (2010-11-09). "Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo". Proceedings of the National Academy of Sciences. 107 (45): 19479–19484. doi:10.1073/pnas.1005165107.

References

  1. ↑ "Professor Xin Lu - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 2018-03-12.
  2. 1 2 "Professor Xin Lu | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2018-03-12.
  3. ↑ "Focus on Xin Lu" (PDF). EMBO Encounters. Issue 20: 5. Winter 2011.
  4. 1 2 3 "Xin Lu Lab". Ludwig Institute.
  5. ↑ https://www.ludwigcancerresearch.org/location/oxford-branch/xin-lu-lab
  6. ↑ "A study of intermediate filament formation using retrovirus-mediated gene transfer - ProQuest". Retrieved 2018-03-12.
  7. 1 2 "DIRECTOR OF LICR OXFORD BRANCH, PROFESSOR XIN LU, PHD FRCPATH, ELECTED TO EUROPEAN MOLECULAR BIOLOGY ORGANIZATION". Ludwig Institute. Oct 21, 2011.
  8. ↑ "Xin Lu — Diversity Projects". www.diversityprojects.ox.ac.uk. Retrieved 2018-03-12.
  9. ↑ "Professor Xin Lu | Magdalen College Oxford". www.magd.ox.ac.uk. Retrieved 2018-03-12.
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