WNT5B

WNT5B
Identifiers
AliasesWNT5B, Wnt family member 5B
External IDsMGI: 98959 HomoloGene: 22530 GeneCards: WNT5B
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.33Start1,529,891 bp[1]
End1,647,243 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

81029

22419

Ensembl

ENSG00000111186

ENSMUSG00000030170

UniProt

Q9H1J7

P22726

RefSeq (mRNA)

NM_030775
NM_032642

NM_001271757
NM_001271758
NM_009525

RefSeq (protein)

NP_110402
NP_116031

NP_001258686
NP_001258687
NP_033551

Location (UCSC)Chr 12: 1.53 – 1.65 MbChr 6: 119.43 – 119.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.[5][6]

The WNT gene family consists of structurally-related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates two transcript variants.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000111186 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030170 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Saitoh T, Katoh M (Jul 2001). "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region". Int J Oncol. 19 (2): 347–51. doi:10.3892/ijo.19.2.347. PMID 11445850.
  6. 1 2 "Entrez Gene: WNT5B wingless-type MMTV integration site family, member 5B".

Further reading

  • Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
  • Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
  • Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". Int. J. Mol. Med. 10 (3): 345–9. doi:10.3892/ijmm.10.3.345. PMID 12165812.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kanazawa A, Tsukada S, Sekine A, et al. (2005). "Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes". Am. J. Hum. Genet. 75 (5): 832–43. doi:10.1086/425340. PMC 1182112. PMID 15386214.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mangioni S, Viganò P, Lattuada D, et al. (2005). "Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor". J. Clin. Endocrinol. Metab. 90 (9): 5349–55. doi:10.1210/jc.2005-0272. PMID 15972578.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.