WNK2

WNK2
Identifiers
AliasesWNK2, NY-CO-43, P/OKcl.13, PRKSDCCAG43, WNK lysine deficient protein kinase 2
External IDsMGI: 1922857 HomoloGene: 19155 GeneCards: WNK2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q22.31Start93,184,916 bp[1]
End93,320,572 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

65268

75607

Ensembl

ENSG00000165238

ENSMUSG00000037989

UniProt

Q9Y3S1

Q3UH66

RefSeq (mRNA)

NM_001282394
NM_006648

NM_001290311
NM_001290313
NM_029361

RefSeq (protein)

NP_001269323
NP_006639

NP_001277240
NP_001277242
NP_083637

Location (UCSC)Chr 9: 93.18 – 93.32 MbChr 13: 49.04 – 49.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.[5][6][7]

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165238 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037989 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
  6. ↑ Verissimo F, Jordan P (Sep 2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
  7. 1 2 "Entrez Gene: WNK2 WNK lysine deficient protein kinase 2".

Further reading

  • Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  • Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res. 61 (5): 2038–46. PMID 11280764.
  • Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Moniz S, Veríssimo F, Matos P, et al. (2007). "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2". Oncogene. 26 (41): 6071–81. doi:10.1038/sj.onc.1210706. PMID 17667937.


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