WBP1

WBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWBP1, WBP-1, WW domain binding protein 1
External IDsMGI: 104710 HomoloGene: 8267 GeneCards: WBP1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.1Start74,458,329 bp[1]
End74,460,891 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23559

22377

Ensembl

ENSG00000239779

ENSMUSG00000030035

UniProt

Q96G27

P97764

RefSeq (mRNA)

NM_012477

NM_001083922
NM_001083923
NM_016757

RefSeq (protein)

NP_036609

NP_001077391
NP_001077392
NP_058037

Location (UCSC)Chr 2: 74.46 – 74.46 MbChr 6: 83.12 – 83.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.[5][6]

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000239779 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030035 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.
  6. 1 2 "Entrez Gene: WBP1 WW domain binding protein 1".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins". Oncogene. 23 (29): 5049–55. doi:10.1038/sj.onc.1207680. PMC 4143251. PMID 15064722.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3: 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
  • Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi:10.1074/jbc.272.27.17070. PMID 9202023.
  • Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.


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