WAPAL

WAPL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4K6J, 5HDT
Identifiers
Aliases	WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor
External IDs	MGI: 2675859 HomoloGene: 41002 GeneCards: WAPL
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	86,521,815 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	34,747,983 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein binding;
Cellular component	• cytoplasm; • cytosol; • cohesin complex; • chromosome; • chromatin; • synaptonemal complex; • chromosome, centromeric region; • cell nucleus; • nucleoplasm;
Biological process	• negative regulation of sister chromatid cohesion; • negative regulation of chromatin binding; • positive regulation of fibroblast proliferation; • negative regulation of DNA replication; • regulation of cohesin loading; • cell division; • regulation of chromosome segregation; • cell cycle; • viral process; • protein localization to chromatin; • response to toxic substance; • mitotic sister chromatid cohesion; • regulation of chromosome condensation; • meiotic chromosome segregation; • mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	23063
	218914
	ENSG00000062650
	ENSMUSG00000041408
	Q7Z5K2
	Q65Z40
	NM_015045; NM_001318328
	NM_001004436; NM_001301330
	NP_001305257; NP_055860
	NP_001004436; NP_001288259
	Wikidata
View/Edit Human	View/Edit Mouse

Wings apart-like protein homolog is a protein that in humans is encoded by the WAPAL gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000062650 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041408 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
↑ Gandhi R, Gillespie PJ, Hirano T (Dec 2006). "Human Wapl Is a Cohesin-binding Protein that Promotes Sister Chromatid Resolution in Mitotic Prophase". Curr Biol. 16 (24): 2406–17. doi:10.1016/j.cub.2006.10.061. PMC 1850625. PMID 17112726.
↑ "Entrez Gene: WAPAL wings apart-like homolog (Drosophila)".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Oikawa K, Ohbayashi T, Kiyono T, et al. (2004). "Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression". Cancer Res. 64 (10): 3545–9. doi:10.1158/0008-5472.CAN-03-3822. PMID 15150110.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Kwiatkowski BA, Ragoczy T, Ehly J, Schubach WH (2004). "Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2". Exp. Cell Res. 300 (1): 223–33. doi:10.1016/j.yexcr.2004.06.028. PMID 15383329.
Kuroda M, Oikawa K, Ohbayashi T, et al. (2005). "A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis". FEBS Lett. 579 (1): 167–72. doi:10.1016/j.febslet.2004.11.070. PMID 15620708.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kueng S, Hegemann B, Peters BH, et al. (2007). "Wapl controls the dynamic association of cohesin with chromatin". Cell. 127 (5): 955–67. doi:10.1016/j.cell.2006.09.040. PMID 17113138.
Ohbayashi T, Oikawa K, Yamada K, et al. (2007). "Unscheduled overexpression of human WAPL promotes chromosomal instability". Biochem. Biophys. Res. Commun. 356 (3): 699–704. doi:10.1016/j.bbrc.2007.03.037. PMID 17382297.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000062650 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041408 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9039502-5] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.

[pmid17112726-6] Gandhi R, Gillespie PJ, Hirano T (Dec 2006). "Human Wapl Is a Cohesin-binding Protein that Promotes Sister Chromatid Resolution in Mitotic Prophase". Curr Biol. 16 (24): 2406–17. doi:10.1016/j.cub.2006.10.061. PMC 1850625. PMID 17112726.

[entrez-7] "Entrez Gene: WAPAL wings apart-like homolog (Drosophila)".

WAPAL

References

Further reading