Vascular endothelial growth factor (VEGF) IRES A

Vascular endothelial growth factor (VEGF) IRES A
Predicted secondary structure and sequence conservation of IRES_VEGF_A
Identifiers
Symbol IRES_VEGF_A
Rfam RF00461
Other data
RNA type Cis-reg; IRES
Domain(s) Eukaryota
GO 0043022
SO 0000243
PDB structures PDBe

This family represents the vascular endothelial growth factor (VEGF) internal ribosome entry site (IRES) A. VEGF is an endothelial cell mitogen with many crucial functions such as embryogenic development and wound healing. The 5' UTR of VEGF mRNA contains two IRES elements which are able to promote efficient translation at the AUG start codon, this family represents IRES A.[1]

References

  1. ↑ Huez, I; Creancier L; Audigier S; Gensac MC; Prats AC; Prats H (1998). "Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA". Mol Cell Biol. 18 (11): 6178&ndash, 6190. PMC 109205. PMID 9774635.
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