Vacuolar interface dermatitis
![](../I/m/Vacuolar_interface_dermatitis_-_high_mag.jpg)
Micrograph of a vacuolar interface dermatitis with dermal mucin, as may be seen in lupus. H&E stain.
Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis where degenerative changes occur at the dermoepidermal junction, with lymphophatic inflammation at the epidermis and dermis.[1] This change is frequently found in lupus erythematosus, erythema multiforme and lichen sclerosis.
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