GDP-L-galactose phosphorylase

GDP-L-galactose phosphorylase
Identifiers
EC number 2.7.7.69
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

GDP-L-galactose phosphorylase (EC 2.7.7.69, VTC2, VTC5) is an enzyme with systematic name GDP:alpha-L-galactose 1-phosphate guanylyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

GDP-L-galactose + phosphate alpha-L-galactose 1-phosphate + GDP

The enzyme catalyses a reaction of the Smirnoff-Wheeler pathway.

References

  1. ↑ Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG (June 2007). "Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants". The Journal of Biological Chemistry. 282 (26): 18879–85. doi:10.1074/jbc.m702094200. PMID 17462988.
  2. ↑ Linster CL, Adler LN, Webb K, Christensen KC, Brenner C, Clarke SG (July 2008). "A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction". The Journal of Biological Chemistry. 283 (27): 18483–92. doi:10.1074/jbc.m802594200. PMC 2441562. PMID 18463094.
  3. ↑ Dowdle J, Ishikawa T, Gatzek S, Rolinski S, Smirnoff N (November 2007). "Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability". The Plant Journal. 52 (4): 673–89. doi:10.1111/j.1365-313x.2007.03266.x. PMID 17877701.
  4. ↑ Müller-Moulé P (September 2008). "An expression analysis of the ascorbate biosynthesis enzyme VTC2". Plant Molecular Biology. 68 (1–2): 31–41. doi:10.1007/s11103-008-9350-4. PMID 18516687.
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