VPS39

VPS39
Identifiers
AliasesVPS39, TLP, VAM6, hVam6p, HOPS complex subunit
External IDsMGI: 2443189 HomoloGene: 41025 GeneCards: VPS39
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q15.1Start42,158,701 bp[1]
End42,208,316 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23339

269338

Ensembl

ENSG00000166887

ENSMUSG00000027291

UniProt

Q96JC1

Q8R5L3

RefSeq (mRNA)

NM_001301138
NM_015289

NM_147153
NM_178851
NM_001363053
NM_001363054

RefSeq (protein)

NP_001288067
NP_056104

NP_671495
NP_849182
NP_001349982
NP_001349983

Location (UCSC)Chr 15: 42.16 – 42.21 MbChr 2: 120.32 – 120.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.[5][6]

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166887 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027291 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS (Jul 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J Cell Biol. 154 (1): 109–122. doi:10.1083/jcb.200102142. PMC 2196876. PMID 11448994.
  6. 1 2 "Entrez Gene: VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Felici A, Wurthner JU, Parks WT, et al. (2003). "TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling". EMBO J. 22 (17): 4465–4477. doi:10.1093/emboj/cdg428. PMC 202370. PMID 12941698.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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