Up-and-down procedure

Up-and-down procedure (or method) is an alternative to the LD50 acute toxicity test.[1][2]

It requires fewer animals to achieve similar accuracy as the LD50 test.[3] However, the U.S. Food and Drug Administration has begun to approve non-animal alternatives.[4][5]

References

  1. ↑ Lipnick, RL; Cotruvo, JA; Hill, RN; Bruce, RD; Stitzel, KA; Walker, AP; Chu, I; Goddard, M; et al. (1995). "Comparison of the up-and-down, conventional LD50, and fixed-dose acute toxicity procedures". Food and Chemical Toxicology. 33 (3): 223–31. doi:10.1016/0278-6915(94)00136-C. PMID 7896233.
  2. ↑ Lichtman, A (1998). "The up-and-down method substantially reduces the number of animals required to determine antinociceptive ED50 values". Journal of Pharmacological and Toxicological Methods. 40 (2): 81–5. doi:10.1016/S1056-8719(98)00041-0. PMID 10100496.
  3. ↑ Acute Oral Toxicity (AOT) Up-And-Down-Procedure
  4. ↑ "Allergan Receives FDA Approval for First-of-Its-Kind, Fully in vitro, Cell-Based Assay for BOTOX® and BOTOX® Cosmetic (onabotulinumtoxinA)". Source: Allergan, Inc. News Provided by Acquire Media. 24 June 2011. Archived from the original on 26 June 2011. Retrieved 26 June 2011.
  5. ↑ "In U.S., Few Alternatives To Testing On Animals". Washington Post. 12 April 2008. Retrieved 2011-06-26.


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