Umatilla virus

Umatilla virus
Virus classification
Group: Group III (dsRNA)
Order: Unassigned
Family: Reoviridae
Subfamily: Sedoreovirinae
Genus: Orbivirus
Species: Umatilla virus

Umatilla virus (UMAV) is a dsRNA virus in the family Reoviridae, subfamily Sedoreovirinae, and the genus Orbivirus. This arbovirus was first isolated in 1969 in Umatilla County, Oregon in a group of Culex pipiens mosquitoes.[1] The viral host is the Passer domesticus bird with the vectors being Culex pipiens and Culex tarsalis mosquitoes.[2] Isolation has occurred in Oregon, Colorado, Texas, and Utah.

Virus structure

According to the Baltimore classification, Reoviridae are in Group III due to their dsRNA genome. This family of viruses have a linear and segmented genomic arrangement and they lack a lipid envelope. Opposed to having a lipid envelope, these viruses pack their genome into a multi-layered capsid; the outer capsid being T=13 and the inner T=2. The family is divided into two subfamilies and UMAV belongs to Sedoreovirinae. This subfamily lacks turrets and therefore has a smooth surface.

UMAV is in the Orbivirus genus, which was originally named after its ring shape. The Umatilla virus genome is broken into ten segments with one packaged per virion. The ten segmented genome encodes for 7 major structural proteins and 3 major non-structural.

The UMAV genome is 19,402 bp long, with 5.695% of the genome being non-coding. With UMAV being in the Reoviridae family, it is a non-enveloped virus, but the core is around 30 nm in diameter. The ten segments of this linear dsRNA in the virus mostly code for a single viral protein.[3]

Replication

Along with other viruses in the Reoviridae family, Umatilla virus replication occurs in the cytoplasm. This virus comes with some of its own replication proteins. Entrance into the host cell occurs through cell receptors endocytosis. This process is due to the interaction with sialic acid on the host.[4] The outer capsid is removed as the virus is entering the host via endocytosis. So that the dsRNA never comes in direct contact with the cytoplasm, early replication occurs in the viral core. Both replication and assembly occur in the cytoplasm of the host cell. Host ribosomes are used to translate the viral RNA into mRNA. Virions self-assemble in they host cell cytoplasm and then exit by budding following host cell death.[4]

Transmission

This virus is transmitted by ticks, mosquitoes, or sand flies and has a range of hosts with the most common being cattle and birds.[3]

References

  1. ↑ "ArboCat Virus: Umatilla (UMAV)". wwwn.cdc.gov. Retrieved 2017-11-02.
  2. ↑ "Umatilla". www.reoviridae.org. Retrieved 2017-11-02.
  3. 1 2 Belaganahalli MN, Maan S, Maan NS, Tesh R, Attoui H, Mertens PP (2011). "Umatilla virus genome sequencing and phylogenetic analysis: identification of stretch lagoon orbivirus as a new member of the Umatilla virus species". PLOS One. 6 (8): e23605. doi:10.1371/journal.pone.0023605. PMC 3163642. PMID 21897849.
  4. 1 2 "Orbivirus". ViralZone. ExPASy. Retrieved 2017-11-02.
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