USP47

USP47
Identifiers
Aliases	USP47, TRFP, ubiquitin specific peptidase 47
External IDs	MGI: 1922246 HomoloGene: 9929 GeneCards: USP47
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	11,959,323 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	112,111,661 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• WD40-repeat domain binding; • peptidase activity; • hydrolase activity; • cysteine-type peptidase activity; • thiol-dependent ubiquitin-specific protease activity; • protein binding; • thiol-dependent ubiquitinyl hydrolase activity; • ubiquitinyl hydrolase activity; • cysteine-type endopeptidase activity;
Cellular component	• cytoplasm; • SCF ubiquitin ligase complex; • nucleoplasm; • cytosol;
Biological process	• ubiquitin-dependent protein catabolic process; • proteolysis; • negative regulation of apoptotic process; • cellular response to UV; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; • DNA repair; • positive regulation of cell growth; • monoubiquitinated protein deubiquitination; • base-excision repair; • negative regulation of G2/M transition of mitotic cell cycle; • response to drug; • negative regulation of transcription, DNA-templated; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular response to DNA damage stimulus; • protein deubiquitination; • positive regulation of canonical Wnt signaling pathway; • regulation of protein stability;
	Sources:Amigo / QuickGO
Orthologs
	55031
	74996
	ENSG00000170242
	ENSMUSG00000059263
	Q96K76
	Q8BY87
	NM_001282659; NM_017944; NM_001330208
	NM_133758; NM_177249; NM_001357952
	NP_001269588; NP_001317137; NP_060414
	NP_598519; NP_796223; NP_001344881
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170242 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059263 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
↑ "Entrez Gene: USP47 ubiquitin specific peptidase 47".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170242 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059263 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.

[entrez-6] "Entrez Gene: USP47 ubiquitin specific peptidase 47".

USP47

References

Further reading