UQCRC1

UQCRC1
Identifiers
AliasesUQCRC1, D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I, ubiquinol-cytochrome c reductase core protein 1
External IDsMGI: 107876 HomoloGene: 2525 GeneCards: UQCRC1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.31Start48,599,002 bp[1]
End48,610,976 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7384

22273

Ensembl

ENSG00000010256

n/a

UniProt

P31930

Q9CZ13

RefSeq (mRNA)

NM_003365

NM_025407

RefSeq (protein)

NP_003356

NP_079683

Location (UCSC)Chr 3: 48.6 – 48.61 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.[4][5]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000010256 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase". J Biol Chem. 268 (28): 21113–9. PMID 8407948.
  5. ↑ "Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I".

Further reading

  • Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991). "Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system". J. Biol. Chem. 266 (4): 2333–8. PMID 1846623.
  • Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain". Biochim. Biophys. Acta. 592 (3): 519–27. doi:10.1016/0005-2728(80)90096-1. PMID 6251869.
  • Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (2): 410. PMID 7951059.
  • Islam MM, Tanaka M, Suzuki H, et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (4): 815. PMID 7981668.
  • Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 32 (5): 797–805. PMID 8069229.
  • Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. doi:10.1007/s004390050988. PMID 10453733.
  • Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)". J. Neurochem. 81 (1): 36–45. doi:10.1046/j.1471-4159.2002.00788.x. PMID 12067236.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kulawiec M, Arnouk H, Desouki MM, et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer". Cancer Biol. Ther. 5 (8): 967–75. doi:10.4161/cbt.5.8.2880. PMID 16775426.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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