UPK2

UPK2
Identifiers
AliasesUPK2, UP2, UPII, uroplakin 2
External IDsMGI: 98913 HomoloGene: 4920 GeneCards: UPK2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q23.3Start118,925,164 bp[1]
End118,958,559 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7379

22269

Ensembl

ENSG00000110375

ENSMUSG00000041523

UniProt

O00526

P38575
Q3SXK0

RefSeq (mRNA)

NM_006760

NM_009476

RefSeq (protein)

NP_006751

NP_033502

Location (UCSC)Chr 11: 118.93 – 118.96 MbChr 9: 44.45 – 44.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Uroplakin-2 is a protein that in humans is encoded by the UPK2 gene.[5][6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110375 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041523 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT (Apr 1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291–7. doi:10.1097/00005392-199811000-00097. PMID 9515818.
  6. ↑ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
  7. ↑ "Entrez Gene: UPK2 uroplakin 2".

Further reading

  • Lin JH, Wu XR, Kreibich G, Sun TT (1994). "Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane". J. Biol. Chem. 269 (3): 1775–84. PMID 7507484.
  • Wu XR, Lin JH, Walz T, et al. (1994). "Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins". J. Biol. Chem. 269 (18): 13716–24. PMID 8175808.
  • Yuasa T, Yoshiki T, Isono T, et al. (1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int. J. Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304.
  • Li SM, Zhang ZT, Chan S, et al. (1999). "Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder". J. Urol. 162 (3 Pt 1): 931–5. doi:10.1097/00005392-199909010-00093. PMID 10458411.
  • Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. doi:10.1016/S0002-9440(10)65206-6. PMC 1867018. PMID 10514386.
  • Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell. 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMC 138628. PMID 12475947.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hirata H, Hisatomi H, Kawakita M, et al. (2004). "Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction". Oncol. Rep. 10 (4): 963–6. doi:10.3892/or.10.4.963. PMID 12792753.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chen F, Zeng F, Tong Q, et al. (2006). "Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector". J. Huazhong Univ. Sci. Technol. Med. Sci. 25 (2): 188–90, 211. doi:10.1007/BF02873573. PMID 16116969.
  • Jenkins D, Bitner-Glindzicz M, Malcolm S, et al. (2007). "Mutation analyses of Uroplakin II in children with renal tract malformations". Nephrol. Dial. Transplant. 21 (12): 3415–21. doi:10.1093/ndt/gfl465. PMID 17012268.


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