UNC93A

UNC93A
Identifiers
AliasesUNC93A, Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A
External IDsMGI: 1933250 HomoloGene: 10356 GeneCards: UNC93A
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q27Start167,271,169 bp[1]
End167,316,019 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

54346

381058

Ensembl

ENSG00000112494

ENSMUSG00000067049

UniProt

Q86WB7

Q710D3

RefSeq (mRNA)

NM_001143947
NM_018974

NM_199252

RefSeq (protein)

NP_001137419
NP_061847

NP_954860

Location (UCSC)Chr 6: 167.27 – 167.32 MbChr 17: 13.11 – 13.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.[5]

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[6][7] It belongs to the atypical SLCs that was recently listed.[6] It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to Unc93B1 and MFSD11.[8][9]

UNC93A is affected by amino acid deprivation in cell cortex cultures[7][8] and starvation in in vivo samples.[8]

It is expressed in neurons, with staining close to the plasma membrane.[8]

Read also [10][11] for functional studies in C.elegans.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Unc-93 homolog A (C. elegans)".
  6. 1 2 Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  7. 1 2 Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
  8. 1 2 3 4 Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
  9. ↑ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS One. 11 (6): e0156912. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  10. ↑ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
  11. ↑ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. PMID 14534247.

Further reading

  • Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (October 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.


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