UDP-N-acetylglucosamine diphosphorylase
| UDP-N-acetylglucosamine diphosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.7.23 | ||||||||
| CAS number | 9023-06-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) is an enzyme that catalyzes the chemical reaction
- UTP + N-acetyl-alpha-D-glucosamine 1-phosphate diphosphate + UDP-N-acetyl-D-glucosamine
Thus, the two substrates of this enzyme are UTP and[N-acetyl-alpha-D-glucosamine 1-phosphate, whereas its two products are diphosphate and UDP-N-acetyl-D-glucosamine.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FWY, 1FXJ, 1G95, 1G97, 1HM0, 1HM8, 1HM9, 1HV9, 1JVD, 1JVG, 1VM8, 2NPO, 2OI5, 2OI6, 2OI7, 2YQC, 2YQH, 2YQJ, and 2YQS.
References
- Pattabiramin TN; Bachhawat BK (1961). "Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain". Biochim. Biophys. Acta. 50: 129&ndash, 134. doi:10.1016/0006-3002(61)91068-X. PMID 13733356.
- Strominger JL; Smith MS (1959). "Uridine diphosphoacetylglucosamine pyrophosphorylase". J. Biol. Chem. 234: 1822&ndash, 1827.