UBR2

UBR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3NY2, 3NY3
Identifiers
Aliases	UBR2, C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3, ubiquitin protein ligase E3 component n-recognin 2
External IDs	MGI: 1861099 HomoloGene: 26151 GeneCards: UBR2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	42,693,504 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	47,010,556 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein binding; • zinc ion binding; • leucine binding; • ubiquitin protein ligase activity; • metal ion binding; • ubiquitin-protein transferase activity; • transferase activity;
Cellular component	• chromatin; • cell nucleus; • ubiquitin ligase complex; • cytoplasm; • cytosol;
Biological process	• cellular response to leucine; • protein catabolic process; • male meiosis I; • ubiquitin-dependent protein catabolic process; • protein ubiquitination; • ubiquitin-dependent protein catabolic process via the N-end rule pathway; • negative regulation of TOR signaling; • chromatin silencing; • histone H2A ubiquitination; • protein polyubiquitination; • reciprocal meiotic recombination; • male meiotic nuclear division; • spermatogenesis; • negative regulation of transposition;
	Sources:Amigo / QuickGO
Orthologs
	23304
	224826
	ENSG00000024048
	ENSMUSG00000023977
	Q8IWV8
	Q6WKZ8
	NM_001184801; NM_015255; NM_001363705
	NM_001177374; NM_146078
	NP_001171730; NP_056070; NP_001350634
	NP_001170845; NP_666190
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase UBR2 is an enzyme that in humans is encoded by the UBR2 gene.^[5]

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003).[supplied by OMIM]^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000024048 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023977 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: UBR2 ubiquitin protein ligase E3 component n-recognin 2".

Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Kwon YT, Xia Z, An JY, et al. (2003). "Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway". Mol. Cell. Biol. 23 (22): 8255–71. doi:10.1128/MCB.23.22.8255-8271.2003. PMC 262401. PMID 14585983.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yin J, Kwon YT, Varshavsky A, Wang W (2005). "RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway". Hum. Mol. Genet. 13 (20): 2421–30. doi:10.1093/hmg/ddh269. PMID 15317757.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kwak KS, Zhou X, Solomon V, et al. (2005). "Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia". Cancer Res. 64 (22): 8193–8. doi:10.1158/0008-5472.CAN-04-2102. PMID 15548684.
Zenker M, Mayerle J, Lerch MM, et al. (2006). "Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)". Nat. Genet. 37 (12): 1345–50. doi:10.1038/ng1681. PMID 16311597.
Matta-Camacho E, Kozlov G, Li F, Gehring K, et al. (2010). "Structural basis of substrate recognition and specificity in the N-end rule pathway". Nat Struct Mol Biol. 17 (10): 1182–7. doi:10.1038/nsmb.1894. PMID 20835242.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000024048 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023977 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: UBR2 ubiquitin protein ligase E3 component n-recognin 2".

UBR2

References

Further reading