UAP1

UAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUAP1, AGX, AGX1, AGX2, SPAG2, UDP-N-acetylglucosamine pyrophosphorylase 1
External IDsMGI: 1334459 HomoloGene: 2342 GeneCards: UAP1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start162,561,506 bp[1]
End162,599,842 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6675

107652

Ensembl

ENSG00000117143

ENSMUSG00000026670

UniProt

Q16222

Q91YN5

RefSeq (mRNA)

NM_133806
NM_001305045
NM_001305046

RefSeq (protein)

NP_001291974
NP_001291975
NP_598567

Location (UCSC)Chr 1: 162.56 – 162.6 MbChr 1: 170.14 – 170.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-N-acetylhexosamine pyrophosphorylase is an enzyme that in humans is encoded by the UAP1 gene.[5][6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117143 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026670 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Mio T, Yabe T, Arisawa M, Yamada-Okabe H (Jul 1998). "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism". J Biol Chem. 273 (23): 14392–7. doi:10.1074/jbc.273.23.14392. PMID 9603950.
  6. ↑ Diekman AB, Goldberg E (Aug 1994). "Characterization of a human antigen with sera from infertile patients". Biol Reprod. 50 (5): 1087–93. doi:10.1095/biolreprod50.5.1087. PMID 8025165.
  7. ↑ "Entrez Gene: UAP1 UDP-N-acteylglucosamine pyrophosphorylase 1".

Further reading

  • Diekman AB, Olson G, Goldberg E (1998). "Expression of the human antigen SPAG2 in the testis and localization to the outer dense fibers in spermatozoa". Mol. Reprod. Dev. 50 (3): 284–93. doi:10.1002/(SICI)1098-2795(199807)50:3<284::AID-MRD4>3.0.CO;2-F. PMID 9621304.
  • Wang-Gillam A, Pastuszak I, Elbein AD (1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". J. Biol. Chem. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
  • Peneff C, Ferrari P, Charrier V, et al. (2002). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". EMBO J. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.


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