Twister sister ribozyme

The twister sister ribozyme is an RNA structure that catalyzes its own cleavage at a specific site. In other words, it is a self-cleaving ribozyme. The twister sister ribozyme was discovered by a bioinformatics strategy ^[1] as an RNA Associated with Genes Associated with Twister and Hammerhead ribozymes, or RAGATH.

The twister sister ribozyme has a possible structural similarity to twister ribozymes.^[1] Some striking similarities were noted, but also surprising differences, such as the absence of the two pseudoknot interactions in the twister ribozyme.^[1] The exact nature of the structural relationship between twister and twister sister ribozymes, if any, has not be determined.

References

1 2 3 Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lünse CE, Breaker RR (2015). "New classes of self-cleaving ribozymes revealed by comparative genomics analysis". Nat. Chem. Biol. 11 (8): 606–10. doi:10.1038/nchembio.1846. PMC 4509812. PMID 26167874.

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[WeinbergKim2015-1] 1 2 3 Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lünse CE, Breaker RR (2015). "New classes of self-cleaving ribozymes revealed by comparative genomics analysis". Nat. Chem. Biol. 11 (8): 606–10. doi:10.1038/nchembio.1846. PMC 4509812. PMID 26167874.