TrkB IRES

TrkB IRES
Predicted secondary structure and sequence conservation of IRES_TrkB
Identifiers
Symbol IRES_TrkB
Rfam RF00547
Other data
RNA type Cis-reg; IRES
Domain(s) Eukaryota
GO 0043022
SO 0000243
PDB structures PDBe

The TrkB internal ribosome entry site (IRES) is an RNA element which is present in the 5' UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites.[1]

See also

References

  1. ↑ Dobson, T; Minic A; Nielsen K; Amiott E; Krushel L (2005). "Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5' leader". Nucleic Acids Res. 33 (9): 2929&ndash, 2941. doi:10.1093/nar/gki605. PMC 1133793. PMID 15908588.
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