Translational efficiency

Translational efficiency or Translation efficiency, in the context of cell biology, is the rate of mRNA translation into proteins within cells.

It has been measured in protein per mRNA per hour.[1] Several RNA elements within mRNAs have been shown to affect the rate. These include miRNA and protein binding sites. RNA structure may also affect translational efficiency through the altered protein or microRNA binding.[2]

See also

References

  1. ↑ Schwanhäusser, Björn; Busse, Dorothea; Li, Na; Dittmar, Gunnar; Schuchhardt, Johannes; Wolf, Jana; Chen, Wei; Selbach, Matthias (May 2011). "Global quantification of mammalian gene expression control". Nature. 473 (7347): 337–342. doi:10.1038/nature10098. PMID 21593866.
  2. ↑ Lu, YF; Mauger, DM; Goldstein, DB; Urban, TJ; Weeks, KM; Bradrick, SS (4 November 2015). "IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance". Scientific Reports. 5: 16037. doi:10.1038/srep16037. PMC 4631997. PMID 26531896.
  • Transterm database online


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.