Toxoplasma lactate dehydrogenase 1 regulatory UTR

LDH1 5'UTR
	Predicted secondary structure and sequence conservation of LDH1 5'UTR
Identifiers
Rfam	RF02697
Other data
Domain(s)	Bacteria
GO	0045182
SO	0005836,0000204
PDB structures	PDBe

In Toxoplasma gondii the translational repression of lactate dehydrogenase 1 (LDH1) was discovered to be mediated through its 5'UTR. A small nucleotide regulatory RNA hairpin was shown to be essential for the repression. It is possible that this hairpin may act as the nucleation site for the binding of an trans-acting factor(s) that allow for the translational repression.^[1]

References

↑ Holmes, Michael; Itaas, Vaunell; Ananvoranich, Sirinart (2014-11-01). "Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin". The FEBS Journal. 281 (22): 5077–5091. doi:10.1111/febs.13048. ISSN 1742-4658. PMID 25223457.

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[1] Holmes, Michael; Itaas, Vaunell; Ananvoranich, Sirinart (2014-11-01). "Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin". The FEBS Journal. 281 (22): 5077–5091. doi:10.1111/febs.13048. ISSN 1742-4658. PMID 25223457.