Tia1 cytotoxic granule-associated rna binding protein
TIA1 cytotoxic granule-associated RNA binding protein is a protein that in humans is encoded by the TIA1 gene.[4]
Function
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.[4]
References
Further reading
- Kawakami A, Tian Q, Streuli M, Poe M, Edelhoff S, Disteche CM, Anderson P (1994). "Intron-exon organization and chromosomal localization of the human TIA-1 gene". J. Immunol. 152 (10): 4937–45. PMID 8176212.
- Dember LM, Kim ND, Liu KQ, Anderson P (1996). "Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities". J. Biol. Chem. 271 (5): 2783–8. doi:10.1074/jbc.271.5.2783. PMID 8576255.
- Bossowski A, Czarnocka B, Bardadin K, Moniuszko A, Łyczkowska A, Czerwinska J, Dadan J, Bossowska A (2010). "Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases". Folia Histochem. Cytobiol. 48 (2): 178–84. doi:10.2478/v10042-010-0022-2. PMID 20675271.
- Aznarez I, Barash Y, Shai O, He D, Zielenski J, Tsui LC, Parkinson J, Frey BJ, Rommens JM, Blencowe BJ (2008). "A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation". Genome Res. 18 (8): 1247–58. doi:10.1101/gr.073155.107. PMC 2493427. PMID 18456862.
- López de Silanes I, Galbán S, Martindale JL, Yang X, Mazan-Mamczarz K, Indig FE, Falco G, Zhan M, Gorospe M (2005). "Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1". Mol. Cell. Biol. 25 (21): 9520–31. doi:10.1128/MCB.25.21.9520-9531.2005. PMC 1265820. PMID 16227602.
- McAlinden A, Liang L, Mukudai Y, Imamura T, Sandell LJ (2007). "Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA". J. Biol. Chem. 282 (33): 24444–54. doi:10.1074/jbc.M702717200. PMID 17580305.
- Anderson P, Nagler-Anderson C, O'Brien C, Levine H, Watkins S, Slayter HS, Blue ML, Schlossman SF (1990). "A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a subpopulation of CD8+ T lymphocytes". J. Immunol. 144 (2): 574–82. PMID 2104899.
- Sugihara M, Tsutsumi A, Suzuki E, Wakamatsu E, Suzuki T, Ogishima H, Hayashi T, Chino Y, Ishii W, Mamura M, Goto D, Matsumoto I, Ito S, Sumida T (2007). "Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis". Arthritis Rheum. 56 (7): 2160–9. doi:10.1002/art.22724. PMID 17599736.
- Singh NN, Seo J, Ottesen EW, Shishimorova M, Bhattacharya D, Singh RN (2011). "TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy". Mol. Cell. Biol. 31 (5): 935–54. doi:10.1128/MCB.00945-10. PMC 3067828. PMID 21189287.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.