Tet methylcytosine dioxygenase 3

TET3
Identifiers
Aliases	TET3, hCG_40738, tet methylcytosine dioxygenase 3
External IDs	MGI: 2446229 HomoloGene: 35360 GeneCards: TET3
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	74,108,176 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	83,459,084 bp[2]
Gene ontology
Molecular function	• DNA binding; • dioxygenase activity; • metal ion binding; • protein binding; • oxidoreductase activity; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • methylcytosine dioxygenase activity; • iron ion binding;
Cellular component	• cytoplasm; • cell nucleus; • chromosome; • female pronucleus; • male pronucleus;
Biological process	• histone H3-K4 trimethylation; • protein O-linked glycosylation; • multicellular organism development; • oxidation-reduction process; • positive regulation of transcription from RNA polymerase II promoter; • chromatin organization; • DNA demethylation of male pronucleus; • DNA demethylation; • 5-methylcytosine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	200424
	194388
	ENSG00000187605
	ENSMUSG00000034832
	O43151
	Q8BG87
	NM_001287491
	NM_183138; NM_001347313
	NP_001274420
	NP_001334242; NP_898961
	Wikidata
View/Edit Human	View/Edit Mouse

Tet methylcytosine dioxygenase 3 is a protein that in humans is encoded by the TET3 gene. ^[5]

Function

Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187605 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034832 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Tet methylcytosine dioxygenase 3". Retrieved 2018-08-13.

Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL (July 2009). "Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies". Blood. 114 (1): 144–7. doi:10.1182/blood-2009-03-210039. PMC 2710942. PMID 19420352.
Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL (July 2009). "Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies". Blood. 114 (1): 144–7. doi:10.1182/blood-2009-03-210039. PMC 2710942. PMID 19420352.
Langemeijer SM, Aslanyan MG, Jansen JH (December 2009). "TET proteins in malignant hematopoiesis". Cell Cycle. 8 (24): 4044–8. doi:10.4161/cc.8.24.10239. PMID 19923888.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Liu N, Wang M, Deng W, Schmidt CS, Qin W, Leonhardt H, Spada F (2013). "Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules". PLoS ONE. 8 (5): e62755. doi:10.1371/journal.pone.0062755. PMC 3653909. PMID 23690950.
Ponnaluri VK, Maciejewski JP, Mukherji M (June 2013). "A mechanistic overview of TET-mediated 5-methylcytosine oxidation". Biochem. Biophys. Res. Commun. 436 (2): 115–20. doi:10.1016/j.bbrc.2013.05.077. PMID 23727577.
Zhang P, Huang B, Xu X, Sessa WC (August 2013). "Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a". Biochem. Biophys. Res. Commun. 437 (3): 368–73. doi:10.1016/j.bbrc.2013.06.082. PMC 3767426. PMID 23820384.
Ito R, Katsura S, Shimada H, Tsuchiya H, Hada M, Okumura T, Sugawara A, Yokoyama A (January 2014). "TET3-OGT interaction increases the stability and the presence of OGT in chromatin". Genes Cells. 19 (1): 52–65. doi:10.1111/gtc.12107. PMID 24304661.
Zhang Q, Liu X, Gao W, Li P, Hou J, Li J, Wong J (February 2014). "Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT)". J. Biol. Chem. 289 (9): 5986–96. doi:10.1074/jbc.M113.524140. PMC 3937666. PMID 24394411.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187605 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034832 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Tet methylcytosine dioxygenase 3". Retrieved 2018-08-13.

Tet methylcytosine dioxygenase 3

Function

References

Further reading