Teg49 small RNA
Teg49 sRNA | |
---|---|
Predicted secondary structure and sequence conservation of Teg49 small RNA | |
Identifiers | |
Rfam | RF02696 |
Other data | |
Domain(s) | Bacteria |
GO | 0009405 |
SO | 0000370 |
PDB structures | PDBe |
Teg49 is a non-coding RNA present in the extended promoter region of the staphylococcal accessory regulator sarA. It was identified by RNA-seq and confirmed by Northern blot. It is modulated by sigB (sarA regulator[1]) and cshA (an ATP-dependant DEAD box RNA helicase[2]) and it most likely contributes to virulence of S. aureus by modulating SarA expression.[3]
References
- ↑ Cheung, A. L.; Chien, Y. T.; Bayer, A. S. (1999-03-01). "Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus". Infection and Immunity. 67 (3): 1331–1337. ISSN 0019-9567. PMC 96465. PMID 10024579.
- ↑ Oun, Stella; Redder, Peter; Didier, Jean-Philippe; François, Patrice; Corvaglia, Anna-Rita; Buttazzoni, Elena; Giraud, Caroline; Girard, Myriam; Schrenzel, Jacques (2013-01-01). "The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus". RNA biology. 10 (1): 157–165. doi:10.4161/rna.22899. ISSN 1555-8584. PMC 3590232. PMID 23229022.
- ↑ Kim, Samin; Reyes, Dindo; Beaume, Marie; Francois, Patrice; Cheung, Ambrose (2014-10-01). "Contribution of teg49 small RNA in the 5' upstream transcriptional region of sarA to virulence in Staphylococcus aureus". Infection and Immunity. 82 (10): 4369–4379. doi:10.1128/IAI.02002-14. ISSN 1098-5522. PMC 4187880. PMID 25092913.
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