Teg49 small RNA

Teg49 sRNA
	Predicted secondary structure and sequence conservation of Teg49 small RNA
Identifiers
Rfam	RF02696
Other data
Domain(s)	Bacteria
GO	0009405
SO	0000370
PDB structures	PDBe

Teg49 is a non-coding RNA present in the extended promoter region of the staphylococcal accessory regulator sarA. It was identified by RNA-seq and confirmed by Northern blot. It is modulated by sigB (sarA regulator^[1]) and cshA (an ATP-dependant DEAD box RNA helicase^[2]) and it most likely contributes to virulence of S. aureus by modulating SarA expression.^[3]

References

↑ Cheung, A. L.; Chien, Y. T.; Bayer, A. S. (1999-03-01). "Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus". Infection and Immunity. 67 (3): 1331–1337. ISSN 0019-9567. PMC 96465. PMID 10024579.
↑ Oun, Stella; Redder, Peter; Didier, Jean-Philippe; François, Patrice; Corvaglia, Anna-Rita; Buttazzoni, Elena; Giraud, Caroline; Girard, Myriam; Schrenzel, Jacques (2013-01-01). "The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus". RNA biology. 10 (1): 157–165. doi:10.4161/rna.22899. ISSN 1555-8584. PMC 3590232. PMID 23229022.
↑ Kim, Samin; Reyes, Dindo; Beaume, Marie; Francois, Patrice; Cheung, Ambrose (2014-10-01). "Contribution of teg49 small RNA in the 5' upstream transcriptional region of sarA to virulence in Staphylococcus aureus". Infection and Immunity. 82 (10): 4369–4379. doi:10.1128/IAI.02002-14. ISSN 1098-5522. PMC 4187880. PMID 25092913.

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[1] Cheung, A. L.; Chien, Y. T.; Bayer, A. S. (1999-03-01). "Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus". Infection and Immunity. 67 (3): 1331–1337. ISSN 0019-9567. PMC 96465. PMID 10024579.

[2] Oun, Stella; Redder, Peter; Didier, Jean-Philippe; François, Patrice; Corvaglia, Anna-Rita; Buttazzoni, Elena; Giraud, Caroline; Girard, Myriam; Schrenzel, Jacques (2013-01-01). "The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus". RNA biology. 10 (1): 157–165. doi:10.4161/rna.22899. ISSN 1555-8584. PMC 3590232. PMID 23229022.

[3] Kim, Samin; Reyes, Dindo; Beaume, Marie; Francois, Patrice; Cheung, Ambrose (2014-10-01). "Contribution of teg49 small RNA in the 5' upstream transcriptional region of sarA to virulence in Staphylococcus aureus". Infection and Immunity. 82 (10): 4369–4379. doi:10.1128/IAI.02002-14. ISSN 1098-5522. PMC 4187880. PMID 25092913.