Tectonin beta-propeller repeat containing 1

TECPR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4TQ1
Identifiers
Aliases	TECPR1, tectonin beta-propeller repeat containing 1
External IDs	MGI: 1917631 HomoloGene: 9120 GeneCards: TECPR1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 98,214,624 bp[1] End 98,252,251 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 144,194,442 bp[2] End 144,223,615 bp[2]
Gene ontology Molecular function • protein binding • phosphatidylinositol-3-phosphate binding • lipid binding Cellular component • integral component of membrane • lysosomal membrane • autophagosome membrane • lysosome • cytoplasmic vesicle • membrane • nucleoplasm • intracellular membrane-bounded organelle Biological process • autophagy • autophagosome maturation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25851	70381
Ensembl	ENSG00000205356	ENSMUSG00000066621
UniProt	Q7Z6L1	Q80VP0
RefSeq (mRNA)	NM_015395	NM_027410 NM_001356992 NM_001356993
RefSeq (protein)	NP_056210	NP_081686 NP_001343921 NP_001343922
Location (UCSC)	Chr 7: 98.21 – 98.25 Mb	Chr 5: 144.19 – 144.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Tectonin beta-propeller repeat containing 1 is a protein that in humans is encoded by the TECPR1 gene. ^[5]

Function

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.