Takafumi Uchida

Takafumi Uchida (born October 1953)[1] is a Japanese Professor of biochemistry at the Tohoku University best known for his development of new technology to sense NO3/NO2 called sNOOOpy.[2]

Research

In 2016 Takafumi Uchida had studied ATF1 and PIN1 and discovered that PIN1 is the key regulator of ATF1 which produces an NPC carcinogenesis in both in vitro and in vivo. In the same study he also proved that Cyclin D1 is a paradigm of PIN1 which controls it and that PIN1 enhances beta-catenin, c-Fos, c-jun and NF-κB.[3] The same year, Takafumi Uchida along with Atsuko Suzuki, Toshiyuki Saeki, Hiroko Ikuji, and Chiyoko Uchida have discovered that brown algae's polyphenol prevents obesity.[4] In 2017 he discovered that GLI1 in combination with PIN1 creates a therapeutic target in hedgehog signaling pathway which increases survival rate among people with medulloblastoma.[5]

References

  1. ↑ "Takafumi Uchida". Retrieved 2017-04-04.
  2. ↑ "A new sensor to detect physiological levels of nitrate and nitrite". AAAS. 2015-12-04. Retrieved 2017-04-04.
  3. ↑ "The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression". Cell Death and Disease. 7 (e2571). 2016. doi:10.1038/cddis.2016.349. PMC 5260992. PMID 28032861.
  4. ↑ Atsuko Suzuki; Toshiyuki Saeki; Hiroko Ikuji; Chiyoko Uchida; Takafumi Uchida (December 30, 2016). "Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes". PLOS ONE. doi:10.1371/journal.pone.0168830. PMC 5201290. PMID 28036348.
  5. ↑ "Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis". 19 (3). Elsevier. March 2017: 216–225. doi:10.1016/j.neo.2017.01.002. PMC 5293723. PMID 28167297.



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