Tabersonine

Tabersonine
Names
IUPAC name
Methyl (5α,12β,19α)-2,3,6,7-tetradehydroaspidospermidine-3-carboxylate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.107.323
Properties
C21H24N2O2
Molar mass 336.44 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus. Tabersonine is hydroxylated at the 16 position by the enzyme tabersonine 16-hydroxylase (T16H) to form 16-hydroxytabersonine.[1] The enzyme leading to its formation is currently unknown. Tabersonine is the first intermediate leading to the formation of vindoline one of the two precursors required for vinblastine biosynthesis.

References

  1. St-Pierre and De Luca (1995) A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus. Plant Physiology. 109(1). 131-139
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