TWF2

TWF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VAC, 2W0I
Identifiers
Aliases	TWF2, A6RP, A6r, PTK9L, MSTP011, twinfilin actin binding protein 2
External IDs	MGI: 1346078 HomoloGene: 5272 GeneCards: TWF2
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	52,239,260 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	106,215,389 bp[2]
Gene ontology
Molecular function	• actin monomer binding; • protein binding; • actin binding; • phosphatidylinositol-4,5-bisphosphate binding; • ATP binding; • protein kinase C binding; • RNA binding; • cadherin binding;
Cellular component	• cell projection; • filopodium; • growth cone; • intracellular; • stereocilium; • perinuclear region of cytoplasm; • extracellular exosome; • cytoskeleton; • lamellipodium; • cytoplasm; • myofibril;
Biological process	• cellular response to retinoic acid; • regulation of actin cytoskeleton organization; • negative regulation of actin filament polymerization; • cellular response to growth factor stimulus; • cell projection organization; • positive regulation of neuron projection development; • positive regulation of axon extension; • positive regulation of lamellipodium assembly; • regulation of microvillus length; • sequestering of actin monomers; • barbed-end actin filament capping;
	Sources:Amigo / QuickGO
Orthologs
	11344
	23999
	ENSG00000247596
	ENSMUSG00000023277
	Q6IBS0
	Q9Z0P5
	NM_007284
	NM_011876
	NP_009215
	NP_036006
	Wikidata
View/Edit Human	View/Edit Mouse

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.^[5]^[6]^[7]

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000247596 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023277 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Rohwer A, Kittstein W, Marks F, Gschwendt M (Aug 1999). "Cloning, expression and characterization of an A6-related protein". Eur J Biochem. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.
↑ Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P (Sep 2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J Biol Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.
1 2 "Entrez Gene: TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila)".

Yamada S, Uchimura E, Ueda T, et al. (2007). "Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen". Biochem. Biophys. Res. Commun. 363 (4): 926–30. doi:10.1016/j.bbrc.2007.09.069. PMID 17910947.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000247596 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023277 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10406962-5] Rohwer A, Kittstein W, Marks F, Gschwendt M (Aug 1999). "Cloning, expression and characterization of an A6-related protein". Eur J Biochem. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.

[pmid12807912-6] Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P (Sep 2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J Biol Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.

[entrez-7] 1 2 "Entrez Gene: TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila)".

TWF2

References

Further reading