TTI2

TTI2
Identifiers
AliasesTTI2, C8orf41, MRT39, TELO2 interacting protein 2
External IDsMGI: 2384576 HomoloGene: 11836 GeneCards: TTI2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p12Start33,473,386 bp[1]
End33,513,601 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

80185

234138

Ensembl

ENSG00000129696

ENSMUSG00000031577

UniProt

Q6NXR4

Q8BGV4

RefSeq (mRNA)

NM_001102401
NM_001265581
NM_025115
NM_001330505

NM_001112729
NM_001199988
NM_144927

RefSeq (protein)

NP_001095871
NP_001252510
NP_001317434
NP_079391

NP_001186917
NP_659176

Location (UCSC)Chr 8: 33.47 – 33.51 MbChr 8: 31.15 – 31.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TELO2 interacting protein 2 is a protein that in humans is encoded by the TTI2 gene. [5]

Function

This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000129696 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031577 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: TELO2 interacting protein 2". Retrieved 2016-12-14.

Further reading

  • Hurov KE, Cotta-Ramusino C, Elledge SJ (2010). "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability". Genes Dev. 24 (17): 1939–50. doi:10.1101/gad.1934210. PMC 2932975. PMID 20810650.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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