TSEN34

TSEN34
Identifiers
AliasesTSEN34, LENG5, PCH2C, SEN34, SEN34L, tRNA splicing endonuclease subunit 34
External IDsMGI: 1913328 HomoloGene: 44182 GeneCards: TSEN34
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.42Start54,189,938 bp[1]
End54,194,536 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

79042

66078

Ensembl

ENSMUSG00000035585

UniProt

Q9BSV6

Q8BMZ5

RefSeq (mRNA)

NM_001077446
NM_001282332
NM_001282333
NM_024075

NM_001164204
NM_001164205
NM_024168

RefSeq (protein)

NP_001070914
NP_001269261
NP_001269262
NP_076980

NP_001157676
NP_001157677
NP_077130

Location (UCSC)Chr 19: 54.19 – 54.19 MbChr 7: 3.69 – 3.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.[5][6][7]

tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][7]

Interactions

TSEN34 has been shown to interact with TSEN2.[6]

References

  1. 1 2 3 ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 GRCh38: Ensembl release 89: ENSG00000278622, ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035585 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842.
  6. 1 2 Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
  7. 1 2 "Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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