TSEN15

TSEN15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GW6
Identifiers
Aliases	TSEN15, C1orf19, sen15, tRNA splicing endonuclease subunit 15, PCH2F
External IDs	MGI: 1913887 HomoloGene: 12002 GeneCards: TSEN15
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	184,123,978 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	152,386,688 bp[2]
Gene ontology
Molecular function	• tRNA-intron endonuclease activity; • nucleic acid binding; • nuclease activity;
Cellular component	• nucleolus; • cell nucleus; • nucleoplasm;
Biological process	• mRNA processing; • RNA phosphodiester bond hydrolysis; • RNA phosphodiester bond hydrolysis, endonucleolytic; • tRNA processing; • tRNA splicing, via endonucleolytic cleavage and ligation; • nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	116461
	66637
	ENSG00000198860
	ENSMUSG00000014980
	Q8WW01
	Q8R3W5
	NM_001127394; NM_001300764; NM_001300766; NM_052965; NM_001363643
	NM_025677
	NP_001120866; NP_001287693; NP_001287695; NP_443197; NP_001350572
	NP_079953
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.^[5]^[6]^[7]

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[7]

Interactions

C1orf19 has been shown to interact with TSEN2.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198860 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014980 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
↑ Song J, Markley JL (Jan 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". J Mol Biol. 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.
1 2 "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".
↑ Paushkin, Sergey V; Patel Meenal; Furia Bansri S; Peltz Stuart W; Trotta Christopher R (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. United States. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. ISSN 0092-8674. PMID 15109492.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Paushkin SV, Patel M, Furia BS, et al. (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198860 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014980 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11318611-5] Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.

[pmid17166513-6] Song J, Markley JL (Jan 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". J Mol Biol. 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.

[entrez-7] 1 2 "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".

[pmid15109492-8] Paushkin, Sergey V; Patel Meenal; Furia Bansri S; Peltz Stuart W; Trotta Christopher R (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. United States. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. ISSN 0092-8674. PMID 15109492.

TSEN15

Interactions

References

Further reading