TRIM6

TRIM6
Identifiers
Aliases	TRIM6, RNF89, tripartite motif containing 6
External IDs	MGI: 2137352 HomoloGene: 14381 GeneCards: TRIM6
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	5,612,958 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	104,235,152 bp[2]
Gene ontology
Molecular function	• protein binding, bridging; • protein tyrosine kinase binding; • ubiquitin protein ligase activity; • zinc ion binding; • transcription factor binding; • metal ion binding; • protein binding; • protein kinase binding; • transferase activity;
Cellular component	• cytoplasm; • cytosol; • intracellular; • cell nucleus;
Biological process	• positive regulation of transcription regulatory region DNA binding; • cellular response to virus; • positive regulation of type I interferon-mediated signaling pathway; • regulation of NIK/NF-kappaB signaling; • free ubiquitin chain polymerization; • cellular response to interferon-beta; • protein trimerization; • protein polyubiquitination; • negative regulation of gene expression; • positive regulation of peptidyl-serine phosphorylation; • negative regulation of stem cell differentiation; • response to lipopolysaccharide; • negative regulation of viral genome replication; • positive regulation of gene expression; • positive regulation of peptidyl-threonine phosphorylation; • protein ubiquitination; • positive regulation of cytokine secretion involved in immune response; • negative regulation of transcription, DNA-templated; • positive regulation of defense response to virus by host;
	Sources:Amigo / QuickGO
Orthologs
	117854
	94088
	ENSG00000121236
	ENSMUSG00000072244
	Q9C030
	Q8BGE7
	NM_058166; NM_001003818; NM_001198644; NM_001198645
	NM_001013616
	NP_001003818; NP_001185573; NP_001185574; NP_477514
	NP_001013637
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.^[5]^[6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000121236 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072244 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
1 2 "Entrez Gene: TRIM6 tripartite motif-containing 6".

Li X, Gold B, O'hUigin C, et al. (2007). "Unique features of TRIM5alpha among closely related human TRIM family members". Virology. 360 (2): 419–33. doi:10.1016/j.virol.2006.10.035. PMID 17156811.
Zhang F, Hatziioannou T, Perez-Caballero D, et al. (2006). "Antiretroviral potential of human tripartite motif-5 and related proteins". Virology. 353 (2): 396–409. doi:10.1016/j.virol.2006.05.035. PMID 16828831.
Li X, Li Y, Stremlau M, et al. (2006). "Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains". J. Virol. 80 (13): 6198–206. doi:10.1128/JVI.00283-06. PMC 1488960. PMID 16775307.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Orimo A, Tominaga N, Yoshimura K, et al. (2001). "Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem". Genomics. 69 (1): 143–9. doi:10.1006/geno.2000.6318. PMID 11013086.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000121236 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072244 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11331580-5] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[entrez-6] 1 2 "Entrez Gene: TRIM6 tripartite motif-containing 6".

TRIM6

References

Further reading