TRERF1

TRERF1
Identifiers
Aliases	TRERF1, BCAR2, HSA277276, RAPA, TREP132, TReP-132, dJ139D8.5, transcriptional regulating factor 1
External IDs	MGI: 2442086 HomoloGene: 14129 GeneCards: TRERF1
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	42,452,051 bp[1]
Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding; • metal ion binding; • RNA polymerase II transcription cofactor activity; • DNA binding; • DNA binding, bending; • ligand-dependent nuclear receptor transcription coactivator activity; • transcription factor binding; • transcription regulatory region DNA binding; • nucleic acid binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • transcription cofactor activity;
Cellular component	• cell nucleus; • histone deacetylase complex; • transcription factor complex; • nucleoplasm; • nucleolus; • cytosol;
Biological process	• multicellular organism development; • cholesterol catabolic process; • regulation of transcription, DNA-templated; • homeostatic process; • steroid biosynthetic process; • positive regulation of transcription, DNA-templated; • transcription, DNA-templated; • regulation of hormone biosynthetic process; • regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	55809
	224829
	ENSG00000124496
	n/a
	Q96PN7
	Q8BXJ2
	NM_001297573; NM_018415; NM_033501; NM_033502
	NM_001097623; NM_172622
	NP_001284502; NP_277037
	NP_001091092; NP_766210
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.^[4]^[5]

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.^[5]

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,^[6] EP300^[4] and CREB-binding protein.^[4]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124496 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 Gizard F, Lavallee B, DeWitte F, Hum DW (Sep 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". J Biol Chem. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.
1 2 "Entrez Gene: TRERF1 transcriptional regulating factor 1".
↑ Gizard, Florence; Lavallee Bernard; DeWitte Frederique; Teissier Elisabeth; Staels Bart; Hum Dean W (Oct 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". J. Biol. Chem. United States. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. ISSN 0021-9258. PMID 12101186.

Dorssers LC, Veldscholte J (1997). "Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells". Int. J. Cancer. 72 (4): 700–5. doi:10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D. PMID 9259413.
Gizard F, Lavallee B, DeWitte F, et al. (2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". J. Biol. Chem. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.
Gizard F, El-Alfy M, Duguay Y, et al. (2003). "Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression". Endocr. Res. 28 (4): 559–74. doi:10.1081/ERC-120016841. PMID 12530663.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gizard F, Teissier E, Dufort I, et al. (2005). "The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells". J. Mol. Endocrinol. 32 (2): 557–69. doi:10.1677/jme.0.0320557. PMID 15072559.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gizard F, Robillard R, Barbier O, et al. (2005). "TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1". Mol. Cell. Biol. 25 (11): 4335–48. doi:10.1128/MCB.25.11.4335-4348.2005. PMC 1140623. PMID 15899840.
Gizard F, Robillard R, Gross B, et al. (2006). "TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone". Mol. Cell. Biol. 26 (20): 7632–44. doi:10.1128/MCB.00326-06. PMC 1636875. PMID 17015480.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124496 - Ensembl, May 2017

[2] "Human PubMed Reference:".

[3] "Mouse PubMed Reference:".

[pmid11349124-4] 1 2 3 Gizard F, Lavallee B, DeWitte F, Hum DW (Sep 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". J Biol Chem. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.

[entrez-5] 1 2 "Entrez Gene: TRERF1 transcriptional regulating factor 1".

[pmid12101186-6] Gizard, Florence; Lavallee Bernard; DeWitte Frederique; Teissier Elisabeth; Staels Bart; Hum Dean W (Oct 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". J. Biol. Chem. United States. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. ISSN 0021-9258. PMID 12101186.

TRERF1

Interactions

References

Further reading