TNPO2

TNPO2
Identifiers
AliasesTNPO2, IPO3, KPNB2B, TRN2, transportin 2
External IDsMGI: 2384849 HomoloGene: 8381 GeneCards: TNPO2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.13Start12,699,194 bp[1]
End12,724,011 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

30000

212999

Ensembl

ENSG00000105576

ENSMUSG00000031691

UniProt

O14787

Q99LG2

RefSeq (mRNA)

NM_013433
NM_001136195
NM_001136196

RefSeq (protein)

NP_001129667
NP_001129668
NP_038461
NP_001129667.1
NP_038461.2

Location (UCSC)Chr 19: 12.7 – 12.72 MbChr 8: 85.04 – 85.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.[5][6][7]

Interactions

TNPO2 has been shown to interact with NXF1,[6] NUP98[8] and Ran (biology).[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105576 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031691 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G (October 1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins". J Cell Biol. 138 (6): 1181–92. doi:10.1083/jcb.138.6.1181. PMC 2132560. PMID 9298975.
  6. 1 2 3 Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proc Natl Acad Sci U S A. 99 (22): 14195–9. Bibcode:2002PNAS...9914195S. doi:10.1073/pnas.212518199. PMC 137860. PMID 12384575.
  7. ↑ "Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)".
  8. ↑ Fontoura, B M; Blobel G; Yaseen N R (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. UNITED STATES. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. ISSN 0021-9258. PMID 10875935.

Further reading

  • Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Blanc V, Kennedy S, Davidson NO (2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling". J. Biol. Chem. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Güttinger S, Mühlhäusser P, Koller-Eichhorn R, et al. (2004). "Transportin2 functions as importin and mediates nuclear import of HuR". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2918–23. Bibcode:2004PNAS..101.2918G. doi:10.1073/pnas.0400342101. PMC 365720. PMID 14981248.
  • Rebane A, Aab A, Steitz JA (2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR". RNA. 10 (4): 590–9. doi:10.1261/rna.5224304. PMC 1370549. PMID 15037768.
  • Lee BJ, Cansizoglu AE, Süel KE, et al. (2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2". Cell. 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMC 3442361. PMID 16901787.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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