TMUB2

TMUB2
Identifiers
AliasesTMUB2, FP2653, transmembrane and ubiquitin like domain containing 2
External IDsMGI: 1919303 HomoloGene: 18581 GeneCards: TMUB2
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79089

72053

Ensembl

n/a

ENSMUSG00000034757

UniProt

Q71RG4

Q3V209

RefSeq (mRNA)

NM_001076674
NM_024107
NM_177441
NM_001330235

NM_028076
NM_001302505
NM_001302506

RefSeq (protein)

NP_001289434
NP_001289435
NP_082352

Location (UCSC)n/aChr 11: 102.28 – 102.29 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.[4][5][6]

Gene

TMUB2 maps on the human chromosome 17, at locus 17q21.31.[6] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[7] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[8]

Expression

TMUB2 is likely ubiquitously expressed throughout the human body.[9] It has a high expression level that is 2.9 times higher than other human genes.[10][11]

Protein

The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[12] These will likely vary in orthologs.

Homology

Paralogs

TMUB1 is the only paralog of TMUB2.[13][14] These proteins share a 38% identity and 51% similarity.[15]

Orthologs

The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[15]

SpeciesCommon nameAccession numberSequence length (aa)Sequence identitySequence similarity
Pan troglodytesChimpanzeeXP_003953053.1301100%100%
Felis CatusCatXP_003997025.132295%95%
Mus MusculusMouseAAH29841.231985%88%
Alligator MississippiensusAlligatorXP_006271613.130661%71%
Haliaeetus leucocephalusBald EagleXP_01055972830159%70%
Danio rerioZebrafishNP_001005573.129147%60%
Acromyrmex echinatiorAntXP_011049429.135423%42%
Nannochloropsis Gaditana*AlgaeEWM26843.147641%54%
Coccidioides immitis RS*Pathogenic FungusXP_001242306.141838%50%

*Limited Query Coverage

Protein Interactions

In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[16][17][18][19] Other proposed interactions include BCL2L13 (BCL2-like 13),[20] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[20] and UBQLN1 (Ubiquilin-1).[20][21][22]

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034757 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (June 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
  5. ↑ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (June 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  6. 1 2 "Entrez Gene: TMUB2 transmembrane and ubiquitin-like domain containing 2".
  7. ↑ UCSC Genome Browser: BLAT Search
  8. ↑ NCBI Gene: TMUB2
  9. ↑ EST Profile Viewer: Human
  10. ↑ Aceview: TMUB2
  11. ↑ NCBI GEO Profiles
  12. ↑ SDSC Biology Workbench 2.0
  13. ↑ GeneCards: TMUB2
  14. ↑ NCBI Gene: TMUB1
  15. 1 2 NCBI BLAST: Basic Local Alignment Search Tool
  16. ↑ Danielsen Jannie M R; Sylvestersen Kathrine B; Bekker-Jensen Simon; Szklarczyk Damian; Poulsen Jon W; Horn Heiko; Jensen Lars J; Mailand Niels; Nielsen Michael L (2011). "Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level". Molecular & Cellular Proteomics. 10 (3): M110.003590. doi:10.1074/mcp.M110.003590. PMC 3047152. PMID 21139048.
  17. ↑ Wagner S. A.; Beli P.; Weinert B. T.; Nielsen M. L.; Cox J.; Mann M.; Choudhary C. (2011). "A Proteome-Wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles". Molecular & Cellular Proteomics. 10: M111.013284. doi:10.1074/mcp.M111.013284. PMC 3205876. PMID 21890473.
  18. ↑ Kim Woong; Bennett Eric J.; Huttlin Edward L.; Guo Ailan; Li Jing; Possemato Anthony; Sowa Mathew E.; et al. (2011). "Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome". Molecular Cell. 44 (2): 325–40. doi:10.1016/j.molcel.2011.08.025. PMC 3200427. PMID 21906983.
  19. ↑ Povlsen Lou K.; Beli Petra; Wagner Sebastian A.; Poulsen Sara L.; Sylvestersen Kathrine B.; Poulsen Jon W.; Nielsen Michael L.; Bekker-Jensen Simon; Mailand Niels; Choudhary Chunaram (2012). "Systems-Wide Analysis of Ubiquitylation Dynamics Reveals a Key Role for PAF15 Ubiquitylation in DNA-Damage Bypass". Nature Cell Biology. 14: 1089–1098. doi:10.1038/ncb2579. PMID 23000965.
  20. 1 2 3 Rolland T, Taşan M, Charloteaux B, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–26. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
  21. ↑ STRING: Functional Protein Association Networks
  22. ↑ BioGRID Database

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–15729. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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